Abstract
To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Basic Helix-Loop-Helix Transcription Factors
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DNA / chemistry
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DNA Primers / chemistry
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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Diabetes Mellitus, Type 1 / genetics*
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Diabetes Mellitus, Type 2 / genetics*
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Female
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Genotype
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Helix-Loop-Helix Motifs
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Humans
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Japan
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Male
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Middle Aged
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Mutation
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Polymerase Chain Reaction
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Trans-Activators / chemistry
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Trans-Activators / genetics*
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Transcription Factors / genetics
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA Primers
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DNA-Binding Proteins
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NEUROD1 protein, human
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Trans-Activators
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Transcription Factors
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DNA