Pd(0)-catalyzed cross-coupling reactions of boron derivatives with a lactam-derived N-Boc enol triflate

EG Occhiato; A Trabocchi; A Guarna

doi:10.1021/ol005759u

Pd(0)-catalyzed cross-coupling reactions of boron derivatives with a lactam-derived N-Boc enol triflate

Org Lett. 2000 May 4;2(9):1241-2. doi: 10.1021/ol005759u.

Authors

EG Occhiato¹, A Trabocchi, A Guarna

Affiliation

¹ Dipartimento di Chimica Organica U. Schiff, Universita di Firenze, Italy.

PMID: 10810717
DOI: 10.1021/ol005759u

Abstract

[formula: see text] The cross-coupling reaction of 2-(1-alkenyl)-1,3,2-benzodioxaboroles, obtained from alkynes and catecholborane, and other boron derivatives with a lactam-derived N-Boc enol triflate occurred under very mild conditions in a THF-water medium employing (Ph3P)2PdCl2 as a catalyst, providing the corresponding 6-substituted N-Boc 3,4-dihydro-2H-pyridines in high yields.