Efficient palladium-catalyzed N-arylation of indoles

Org Lett. 2000 May 18;2(10):1403-6. doi: 10.1021/ol005728z.

Abstract

[equation--see text] The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron-rich phosphines as the supporting ligand in combination with Pd(2)(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bromides
  • Catalysis
  • Chlorides
  • Drug Design
  • Indoles / chemistry*
  • Iodides
  • Models, Molecular
  • Molecular Structure
  • Palladium*
  • Structure-Activity Relationship

Substances

  • Bromides
  • Chlorides
  • Indoles
  • Iodides
  • Palladium