Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma

G Liu; P Ghadirian; D Vesprini; N Hamel; A J Paradis; G Lal; S Gallinger; S A Narod; W D Foulkes

doi:10.1054/bjoc.2000.1221

Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma

Br J Cancer. 2000 May;82(10):1646-9. doi: 10.1054/bjoc.2000.1221.

Authors

G Liu¹, P Ghadirian, D Vesprini, N Hamel, A J Paradis, G Lal, S Gallinger, S A Narod, W D Foulkes

Affiliation

¹ Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Canada.

Abstract

A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / enzymology
Adenocarcinoma / genetics*
Adult
Aged
Aged, 80 and over
Case-Control Studies
Cytochrome P-450 CYP1A1 / genetics*
Female
Genotype
Glutathione Transferase / genetics*
Humans
Male
Middle Aged
Odds Ratio
Pancreatic Neoplasms / enzymology
Pancreatic Neoplasms / genetics*
Polymorphism, Genetic*
Prospective Studies
Regression Analysis
Risk

Substances

Cytochrome P-450 CYP1A1
glutathione S-transferase T1
Glutathione Transferase
glutathione S-transferase M1