Abstract
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acids / pharmacology
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Animals
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Anisomycin / pharmacology
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Dendrites / drug effects
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Dendrites / metabolism*
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Electric Stimulation
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Excitatory Amino Acid Antagonists / pharmacology
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Hippocampus / metabolism*
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Hippocampus / physiology
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Methoxyhydroxyphenylglycol / analogs & derivatives
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Methoxyhydroxyphenylglycol / pharmacology
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Nerve Tissue Proteins / antagonists & inhibitors
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Neural Inhibition / drug effects
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Neural Inhibition / physiology*
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Protein Biosynthesis / drug effects
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Protein Synthesis Inhibitors / pharmacology
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RNA, Messenger / metabolism
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Rats
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Receptors, Metabotropic Glutamate / physiology*
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Xanthenes / pharmacology
Substances
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Amino Acids
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Excitatory Amino Acid Antagonists
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LY 341495
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Nerve Tissue Proteins
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Protein Synthesis Inhibitors
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RNA, Messenger
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Receptors, Metabotropic Glutamate
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Xanthenes
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Methoxyhydroxyphenylglycol
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Anisomycin
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3,4-dihydroxyphenylglycol