Abstract
Several 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones have been synthesized and tested in vivo on mouse passive avoidance test, to evaluate their nootropic activity. The results show that they represent a new class of nootropic drugs with a pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the reference. Among the compounds studied, 7 (DM 232) shows outstanding potency, being active at the dose of 0. 001 mg kg(-1) sc.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-Agonists
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Amnesia / chemically induced
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Amnesia / drug therapy
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Amnesia / prevention & control
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Animals
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Avoidance Learning / drug effects
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Baclofen
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Clonidine
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Dose-Response Relationship, Drug
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Drug Design*
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GABA Agonists
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Mecamylamine
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Mice
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Molecular Structure
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Muscarinic Antagonists
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Nicotine / antagonists & inhibitors
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Nootropic Agents / chemical synthesis*
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Nootropic Agents / pharmacology*
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Piperazines / chemical synthesis*
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Piperazines / pharmacology*
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Piperazines / therapeutic use
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Piracetam / pharmacology
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology*
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Pyrroles / therapeutic use
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Scopolamine
Substances
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Adrenergic alpha-Agonists
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GABA Agonists
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Muscarinic Antagonists
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Nootropic Agents
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Piperazines
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Pyrroles
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Mecamylamine
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Nicotine
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Scopolamine
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Baclofen
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Clonidine
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DM 232
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Piracetam