A simple approach to DOTAP and its analogs bearing different fatty acids

U Massing; J T Kley; L Gürtesch; S Fankhaenel

doi:10.1016/s0009-3084(00)00121-3

A simple approach to DOTAP and its analogs bearing different fatty acids

Chem Phys Lipids. 2000 Apr;105(2):189-91. doi: 10.1016/s0009-3084(00)00121-3.

Authors

U Massing¹, J T Kley, L Gürtesch, S Fankhaenel

Affiliation

¹ Department of Medicinal Oncology, Tumor Biology Center, Freiburg, Germany. [email protected]

PMID: 10823466
DOI: 10.1016/s0009-3084(00)00121-3

Abstract

A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallization
Fatty Acids / chemistry*
Fatty Acids, Monounsaturated / chemical synthesis*
Fatty Acids, Monounsaturated / isolation & purification
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / isolation & purification
Lipids / chemistry
Magnetic Resonance Spectroscopy
Quaternary Ammonium Compounds / chemical synthesis*
Quaternary Ammonium Compounds / isolation & purification

Substances

Fatty Acids
Fatty Acids, Monounsaturated
Fluorescent Dyes
Lipids
Quaternary Ammonium Compounds
1,2-dioleoyloxy-3-(trimethylammonium)propane