Abstract
[formula: see text] The prostaglandins are potent natural products taking part in many biological processes. The "convergent generation of diversity" from a "toolbox" of prostanoid components, augmented with additional polymer-supported transformations, can enable construction of valuable libraries. A parallel-pool strategy was used to assemble a small library of prostanoids. The inhibition of a herpes-family virus demonstrated the potential for new drug discovery.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Chromatography, High Pressure Liquid
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Cytomegalovirus / drug effects
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Ganciclovir / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Peptide Library
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Prostaglandins / chemical synthesis*
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Prostaglandins / pharmacology*
Substances
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Antiviral Agents
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Peptide Library
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Prostaglandins
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Ganciclovir