Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta?

X Montalban; I Durán; J Río; I Sáez-Torres; M Tintoré; E M Martínez-Cáceres

doi:10.1007/s004150050580

Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta?

J Neurol. 2000 Apr;247(4):259-62. doi: 10.1007/s004150050580.

Authors

X Montalban¹, I Durán, J Río, I Sáez-Torres, M Tintoré, E M Martínez-Cáceres

Affiliation

¹ Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital General Universitari Vall d'Hebron, Barcelona, Spain. [email protected]

PMID: 10836616
DOI: 10.1007/s004150050580

Abstract

Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever generally have increased levels of interleukin-6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cohort Studies
Female
Flow Cytometry
Humans
In Vitro Techniques
Influenza, Human / complications*
Interferon-beta / therapeutic use*
Interleukin-10 / blood
Interleukin-6 / blood
Male
Multiple Sclerosis / complications
Multiple Sclerosis / drug therapy*
Predictive Value of Tests
Retrospective Studies
Tumor Necrosis Factor-alpha / metabolism

Substances

Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-10
Interferon-beta