The authors tried to know specificity of aging in persons with Down syndrome (DS) from the aspect of electroencephalograph (EEG) frequency changes through the cross-sectional and longitudinal studies, in comparison with normal persons as well as those with mentally retardation except the Down syndrome (non-DS MR). Subjects for a cross-sectional study were 265 persons with DS, 242 with non-DS MR and 239 healthy persons, and subjects for a follow-up study were 28 persons with DS and 14 with non-DS MR, whose EEGs were recorded repeatedly once a year during 8 or 9 years. Resting EEGs from the frontal, central and occipital regions were examined through power spectrum. In the cross-sectional study, the number of subjects with DS who showed dominant component within 8 Hz band of the basic rhythm reached maximum in its appearance rate at 40-44 years of age in the occipital area, but this slowing progressed already at 30-34 years of age. While in non-DS MR, the number of subjects who showed dominant component at 8 Hz reached maximum at 45-49 years of age, and this slowing of the basic rhythm was not so clear as in DS. In the follow-up study for subjects with DS, although the lowering in EEG frequency to 8 Hz took place in various years of age individually, earlier distinct decrease of the frequency was commonly noticed. These earlier steep lowering of EEG frequency was discussed in relation to the senile signs and to the decline of brain function referring to Alzheimer disease.