Non-aqueous capillary electrophoretic enantioseparation of N-derivatized amino acids using cinchona alkaloids and derivatives as chiral counter-ions

J Chromatogr A. 2000 Apr 14;875(1-2):353-60. doi: 10.1016/s0021-9673(00)00083-2.

Abstract

A non-aqueous capillary electrophoretic method developed with quinine and tert.-butyl carbamoylated quinine as chiral selectors for the enantioseparation of N-protected amino acids was applied to the investigation of other quinine derivatives as chiral additives. The optimum composition of the background electrolyte was found to be 12.5 mM ammonia, 100 mM octanoic acid and 10 mM chiral selector in an ethanol-methanol (60:40, v/v) mixture. Under these conditions, a series of chiral acids, as various benzoyl, 3,5-dinitrobenzoyl and 3,5-dinitrobenzyloxycarbonyl amino acid derivatives were investigated with regards to selectand-selector relationships and enantioselectivity employing quinine, quinidine, cinchonine, cinchonidine, tert.-butyl carbamoylated quinine, tert.-butyl carbamoylated quinidine, dinitrophenyl carbamoylated quinine and cyclohexyl carbamoylated quinine as chiral selector.

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / isolation & purification*
  • Cinchona Alkaloids / chemistry*
  • Electrophoresis, Capillary / methods*
  • Spectrophotometry, Ultraviolet
  • Stereoisomerism

Substances

  • Amino Acids
  • Cinchona Alkaloids