Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

W P Spooren; F Gasparini; H van der Putten; M Koller; S Nakanishi; R Kuhn

doi:10.1016/s0014-2999(00)00269-7

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

Eur J Pharmacol. 2000 May 26;397(1):R1-2. doi: 10.1016/s0014-2999(00)00269-7.

Authors

W P Spooren¹, F Gasparini, H van der Putten, M Koller, S Nakanishi, R Kuhn

Affiliation

¹ Novartis Pharma AG, Nervous System Research, WKL 126.3.64, CH-4002, Basel, Switzerland. [email protected]

PMID: 10844118
DOI: 10.1016/s0014-2999(00)00269-7

Abstract

In metabotropic glutamate receptor 2 (mGlu(2)) knockout mice, the group 2 metabotropic glutamate receptor agonist LY314582 (20 mg/kg, i.p.), a racemate of LY354740, inhibits neither spontaneous nor phencyclidine (PCP)-induced (2.5 mg/kg, s.c.) locomotor activity. Since LY314582 attenuated spontaneous and PCP-induced locomotor activity in wild-type control mice, these data indicate that the effects of LY314582 are mediated via the mGlu(2) receptor and not via the mGlu(3) receptor.

MeSH terms

Analysis of Variance
Animals
Bridged Bicyclo Compounds / pharmacology*
Excitatory Amino Acid Agonists / pharmacology*
Excitatory Amino Acid Antagonists / pharmacology*
Female
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Knockout
Motor Activity / drug effects*
Phencyclidine / pharmacology*
Receptors, Metabotropic Glutamate / genetics
Receptors, Metabotropic Glutamate / physiology*

Substances

Bridged Bicyclo Compounds
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor 2
Phencyclidine
eglumetad