Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods

Ther Drug Monit. 2000 Jun;22(3):354-65. doi: 10.1097/00007691-200006000-00019.

Abstract

As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Amikacin / pharmacokinetics
  • Animals
  • Anti-Bacterial Agents / pharmacokinetics
  • Bayes Theorem
  • Computer Simulation
  • Humans
  • Models, Biological*
  • Models, Statistical*
  • Nonlinear Dynamics
  • Pharmacokinetics*
  • Statistics, Nonparametric
  • Vancomycin / pharmacokinetics

Substances

  • Anti-Bacterial Agents
  • Vancomycin
  • Amikacin