Abstract
A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.
MeSH terms
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Antirheumatic Agents / adverse effects*
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Arthritis, Rheumatoid / drug therapy*
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Female
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Humans
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Lymphoma, B-Cell / chemically induced*
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Lymphoma, B-Cell / pathology
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Lymphoma, Large B-Cell, Diffuse / chemically induced
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Lymphoma, Large B-Cell, Diffuse / pathology
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Methotrexate / adverse effects*
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Middle Aged
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / pathology
Substances
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Antirheumatic Agents
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Methotrexate