Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis

J Rheumatol. 2000 Jun;27(6):1546-9.

Abstract

A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.

Publication types

  • Case Reports

MeSH terms

  • Antirheumatic Agents / adverse effects*
  • Arthritis, Rheumatoid / drug therapy*
  • Female
  • Humans
  • Lymphoma, B-Cell / chemically induced*
  • Lymphoma, B-Cell / pathology
  • Lymphoma, Large B-Cell, Diffuse / chemically induced
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Methotrexate / adverse effects*
  • Middle Aged
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / pathology

Substances

  • Antirheumatic Agents
  • Methotrexate