Abstract
We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine for gene delivery, are described and discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bisbenzimidazole / chemistry*
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Chemical Phenomena
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Chemistry, Physical
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DNA / chemistry*
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DNA / genetics
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Electrophoresis, Polyacrylamide Gel
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Ethidium / chemistry
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Fluorescent Dyes
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Gene Transfer Techniques*
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Genetic Vectors
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Hydrogen Bonding
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Lipids
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Quaternary Ammonium Compounds / chemistry
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Spectrophotometry, Ultraviolet
Substances
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Fluorescent Dyes
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Lipids
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Quaternary Ammonium Compounds
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DNA
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Ethidium
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Bisbenzimidazole