Abstract
We have identified a new splicing variant of the gene "novel amplified in breast cancer 1," NABC1 (HGMW-approved symbol BCAS1). This variant, which we call NABC1_5B, uses a previously unidentified 135-bp exon. Also in this report, we confirm that NABC1 is overexpressed in breast tumors and show that both NABC1 and NABC1_5B are downregulated in colorectal tumors.
MeSH terms
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Alternative Splicing*
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Amino Acid Sequence
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Breast / metabolism
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Colon / metabolism
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / metabolism
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Down-Regulation
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Expressed Sequence Tags
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Molecular Sequence Data
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Rectum / metabolism
Substances
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BCAS1 protein, human
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Neoplasm Proteins