Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis

Lancet. 2000 May 27;355(9218):1885-6. doi: 10.1016/S0140-6736(00)02297-2.

Abstract

We have found that mannose-binding lectin binds to Burkholderia cepacia, an important pathogen in patients with cystic fibrosis, and leads to complement activation, but that this is not the case for Pseudomonas aeruginosa, the more common colonising organism in this disease. We suggest that patients with cystic fibrosis with mannose-binding-lectin deficiency will be at particular risk of B cepacia colonisation.

Publication types

  • Letter

MeSH terms

  • Burkholderia cepacia / isolation & purification
  • Burkholderia cepacia / metabolism*
  • Burkholderia cepacia / pathogenicity
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Collectins
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / metabolism*
  • Cystic Fibrosis / microbiology
  • Electrophoresis, Gel, Pulsed-Field
  • Genotype
  • Humans
  • Pseudomonas aeruginosa / metabolism*
  • Pseudomonas aeruginosa / pathogenicity
  • Sputum / microbiology

Substances

  • Carrier Proteins
  • Collectins