Abstract
Two new lupane derivatives, 3beta,6alpha-dihydroxylup-20(29)-ene (1) and 6alpha-hydroxylup-20(29)-en-3beta-octadecanoate (2), have been isolated from the stems of Periploca aphylla, in addition to beta-sitosterol and lupeol. The structures of 1 and 2 were determined by spectral and chemical methods. Compound 1 showed strong inhibition of alpha-glucosidase type VI and a moderate antibacterial activity.
MeSH terms
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Bacillus cereus / drug effects
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Escherichia coli / drug effects
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Glycoside Hydrolase Inhibitors
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Magnoliopsida / chemistry*
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Microbial Sensitivity Tests
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Molecular Conformation
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Plant Stems / chemistry
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Proteus mirabilis / drug effects
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Salmonella typhi / drug effects
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Staphylococcus / drug effects
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Streptococcus pyogenes / drug effects
Substances
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors