Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells

Nat Cell Biol. 2000 Jul;2(7):461-2. doi: 10.1038/35017105.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / enzymology
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases
  • Endopeptidases / metabolism*
  • Enzyme Activation
  • Membrane Proteins / deficiency*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Mutation
  • Presenilin-1
  • Presenilin-2
  • Stem Cells / enzymology*
  • Stem Cells / metabolism

Substances

  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • Presenilin-1
  • Presenilin-2
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • Bace1 protein, mouse