Abstract
[structure: see text] The constraint of dipeptides with linkers derived from 6-aminocaproic acid (Aca) is a useful means of constructing a beta-turn peptidomimetic. The extension of this concept to the mimicry of a tripeptide entails the incorporation of a side chain moiety on either end of the Aca chain. The synthesis and conformational analysis of two exemplary compounds is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aminocaproic Acid / chemistry
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Circular Dichroism
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Crystallography, X-Ray
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Dipeptides / chemical synthesis
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Dipeptides / chemistry*
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Glycine / chemical synthesis
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Glycine / chemistry*
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Molecular Conformation
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Molecular Mimicry
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Molecular Structure
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Protein Structure, Secondary
Substances
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Dipeptides
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Glycine
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Aminocaproic Acid