Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus

Lancet. 2000 Jun 24;355(9222):2220-1. doi: 10.1016/S0140-6736(00)02410-7.

Abstract

In seven selected patients with dystonia musculorum deformans-1 generalised dystonia (DYT1), continuous bilateral stimulation of the globus pallidus internus was associated with substantial improvement of dystonia and functional disability.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Carrier Proteins / genetics
  • Child
  • Dystonia Musculorum Deformans / genetics
  • Dystonia Musculorum Deformans / physiopathology
  • Dystonia Musculorum Deformans / therapy*
  • Electric Power Supplies
  • Electric Stimulation Therapy / instrumentation
  • Electric Stimulation Therapy / methods*
  • Electrodes, Implanted
  • Follow-Up Studies
  • Globus Pallidus / physiopathology*
  • Humans
  • Magnetic Resonance Imaging
  • Molecular Chaperones*
  • Mutation / genetics
  • Recovery of Function
  • Stereotaxic Techniques
  • Walking / physiology

Substances

  • Carrier Proteins
  • Molecular Chaperones
  • TOR1A protein, human