Abstract
Melanin-specific reagents revealed melanin in cryptococcal cell walls from human brain tissue, and fungal-cell melanin "ghosts" were recovered from infected tissue. The results indicate that Cryptococcus neoformans melanises during human infection.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphotericin B / therapeutic use
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Animals
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Antifungal Agents / therapeutic use
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Brain / pathology*
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Cryptococcosis / drug therapy
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Cryptococcosis / metabolism*
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Cryptococcus neoformans / enzymology
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Cryptococcus neoformans / isolation & purification
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Cryptococcus neoformans / metabolism*
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Dopamine Antagonists / therapeutic use
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Humans
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Melanins / biosynthesis*
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Rodentia
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Trifluoperazine / therapeutic use
Substances
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Antifungal Agents
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Dopamine Antagonists
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Melanins
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Trifluoperazine
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Amphotericin B