Abstract
Several 1,2,3,4-tetrahydro- and 7-N-hydroxycarbamate derivatives of the natural product rapamycin were prepared and assayed for their immunosuppressive and antifungal profiles. Substitutions at the 7-position indicate the possibility of a differentiated immunosuppressive to antifungal profile, whereas 40-position variants of the tetrahydro-analogues did not show similar differentiated activity.
MeSH terms
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Biopharmaceutics
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Candida / drug effects
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Chemistry, Pharmaceutical
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Humans
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Signal Transduction
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Sirolimus / analogs & derivatives*
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Sirolimus / chemistry
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Sirolimus / pharmacology*
Substances
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Antifungal Agents
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Immunosuppressive Agents
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Sirolimus