Abstract
Lipidic glycosides with amino alkyl pendent groups were synthesized and evaluated for in vitro DNA transfection activity. The first representative of this new class of cationic lipids showed good gene delivery and low toxicity to HeLa and 3T3 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Animals
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Anions
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DNA / administration & dosage*
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Glycosides / chemistry*
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HeLa Cells
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Humans
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Lipids / chemical synthesis*
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Lipids / chemistry
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Lipids / pharmacology*
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Mice
Substances
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Anions
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Glycosides
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Lipids
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DNA