Helicobacter pylori, a bacteria first described in 1984, since that time is linked with chronic gastritis and duodenitis. Dyspeptic symptoms and chronic gastritis are common in patients with chronic renal failure (CRF). The aim of the study was to evaluate of Helicobacter pylori-specific IgG and IgA prevalence in 73 CRF children and possible link of H. pylori infection and dyspeptic symptoms. Anti-H. pylori IgG antibodies were present in 20.5% CRF children (treated conservatively--21%; on CAPD--9%; chronically hemodialysed--29.6%), IgA antibodies was present only in 3 dialysed children (4.1%). Comparing to adult CRF patient, a lower rate of H. pylori infection was observed. No correlation between H. pylori seropositivity and a presence of dyspeptic symptoms was observed. Prevalence of H. pylori antibodies was higher in older CRF children and adolescents.