Functions of tetramer-stained HIV-specific CD4(+) and CD8(+) T cells

Curr Opin Immunol. 2000 Aug;12(4):370-4. doi: 10.1016/s0952-7915(00)00102-3.

Abstract

Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HIV infection remains to be determined.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / therapeutic use
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / virology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / virology
  • Drug Therapy, Combination
  • Fluorescent Dyes
  • HIV / immunology*
  • HIV Antigens / immunology
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Staining and Labeling / methods

Substances

  • Anti-HIV Agents
  • Fluorescent Dyes
  • HIV Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II