Abstract
Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HIV infection remains to be determined.
MeSH terms
-
Animals
-
Anti-HIV Agents / therapeutic use
-
CD4-Positive T-Lymphocytes / immunology*
-
CD4-Positive T-Lymphocytes / virology
-
CD8-Positive T-Lymphocytes / immunology*
-
CD8-Positive T-Lymphocytes / virology
-
Drug Therapy, Combination
-
Fluorescent Dyes
-
HIV / immunology*
-
HIV Antigens / immunology
-
HIV Infections / drug therapy
-
HIV Infections / immunology*
-
Histocompatibility Antigens Class I / immunology*
-
Histocompatibility Antigens Class II / immunology*
-
Humans
-
Staining and Labeling / methods
Substances
-
Anti-HIV Agents
-
Fluorescent Dyes
-
HIV Antigens
-
Histocompatibility Antigens Class I
-
Histocompatibility Antigens Class II