Increase awareness and publicity of human immunodeficiency virus (HIV) has fostered a heightened sense of concern regarding the transmission of infectious agents during sports and athletic competition. Although the potential risk is low, there are other unanswered questions and issues regarding infectious disease and sports. Viral hepatitis is a common infection and predominantly affects the young who are most likely to lead active lives and engage in both amateur and competitive sport-related activity. This article summarizes the common forms of viral hepatitis and the associated clinical syndromes. In addition, a review of the literature addressing the effect of exercise and the various states of liver disease is presented. Finally, I will address the question regarding participation and return to physical activity following acute viral hepatitis, as well as chronic hepatitis.