Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile

Arch Gen Psychiatry. 2000 Aug;57(8):812-3. doi: 10.1001/archpsyc.57.8.812.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circadian Rhythm / drug effects
  • Cytochrome P-450 Enzyme System / drug effects
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Therapy, Combination
  • Female
  • Fluvoxamine / blood
  • Fluvoxamine / pharmacokinetics*
  • Fluvoxamine / therapeutic use*
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / metabolism
  • Melatonin / blood
  • Melatonin / metabolism*
  • Melatonin / therapeutic use*
  • Middle Aged
  • Selective Serotonin Reuptake Inhibitors / blood
  • Selective Serotonin Reuptake Inhibitors / pharmacokinetics*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Sleep / drug effects
  • Sleep Initiation and Maintenance Disorders / blood
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Sleep Initiation and Maintenance Disorders / metabolism
  • Treatment Outcome

Substances

  • Serotonin Uptake Inhibitors
  • Cytochrome P-450 Enzyme System
  • Melatonin
  • Fluvoxamine
  • Hydrocortisone