Abstract
Objective:
To explore the role of two membrane proteins, p170 and p26, in clinical drug resistance and their correlation.
Methods:
The expression of p170 and p26 in bone marrow cells from 39 acute leukemia patients were detected by flow cytometry.
Results:
The expression ratios of p170 and p26 were 15.89% +/- 4.41% and 17.32% +/- 10.20%, respectively, in previously untreated group, and 31.02% +/- 14.33% and 33.78% +/- 15.97%, respectively, in refractory/relapse group. The difference between the two groups was significant, while there were no correlation between p170 and p26 (r = -0.1578, P > 0.5).
Conclusion:
Both p170 and p26 were related to clinical multidrug resistance, but the mechanisms were different.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis*
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Adolescent
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Adult
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Aged
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Autoantigens*
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Calcium-Binding Proteins / biosynthesis
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Child
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Drug Resistance, Multiple*
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Drug Resistance, Neoplasm
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Eye Proteins / biosynthesis
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Female
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Genes, bcl-2
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Golgi Matrix Proteins
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Humans
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Leukemia, Myeloid, Acute / drug therapy
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Leukemia, Myeloid, Acute / genetics*
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Male
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Membrane Proteins / biosynthesis
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Middle Aged
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
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Recoverin
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Autoantigens
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Calcium-Binding Proteins
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Eye Proteins
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GOLGA3 protein, human
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Golgi Matrix Proteins
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Membrane Proteins
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Proto-Oncogene Proteins c-bcl-2
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RCV1 protein, Bos taurus
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Recoverin