Abstract
Chemoprophylaxis against HIV after accidental blood exposures represents a new indication for antiretroviral drugs. Efficacy has been suggested by the results of a case-control study in health care workers and the reduction of mother to infant transmission of HIV with zidovudine. The post-exposure treatment should be given as soon as possible, and in the latest at 48 hours. National guidelines recommend a triple therapy with or without protease inhibitor, adapted to the source patient. The evaluation of efficacy needs a standardized follow-up.
MeSH terms
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Anti-HIV Agents / therapeutic use*
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Case-Control Studies
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Drug Therapy, Combination
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France / epidemiology
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HIV Infections / epidemiology
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HIV Infections / etiology*
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HIV Infections / prevention & control*
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HIV Protease Inhibitors / therapeutic use
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Health Personnel / statistics & numerical data
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Humans
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Infectious Disease Transmission, Vertical / prevention & control
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Infectious Disease Transmission, Vertical / statistics & numerical data
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Needlestick Injuries / complications*
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Needlestick Injuries / epidemiology
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Occupational Exposure / prevention & control
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Occupational Exposure / statistics & numerical data
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Patient Selection
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Practice Guidelines as Topic
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Risk Factors
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Time Factors
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Zidovudine / therapeutic use*
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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Zidovudine