The rat vertex-middle latency auditory-evoked potential as indicator of anaesthetic depth: a comparison with evoked-reflex testing

Z L Haberham; W E van den Brom; A J Venker-van Haagen; H N de Groot; V Baumans; L J Hellebrekers

doi:10.1016/s0006-8993(00)02504-x

The rat vertex-middle latency auditory-evoked potential as indicator of anaesthetic depth: a comparison with evoked-reflex testing

Brain Res. 2000 Aug 11;873(2):287-90. doi: 10.1016/s0006-8993(00)02504-x.

Authors

Z L Haberham¹, W E van den Brom, A J Venker-van Haagen, H N de Groot, V Baumans, L J Hellebrekers

Affiliation

¹ Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD, Utrecht, The Netherlands. [email protected]

PMID: 10930556
DOI: 10.1016/s0006-8993(00)02504-x

Abstract

We investigated whether components from the rat Vx-MLAEP could be used to assess depth of anaesthesia induced by propofol. Propofol decreased MLAEP amplitudes and increased latencies. We propose that the P(16)-N(22) wave in the rat MLAEP is similar to the human P1, and that recovery of this wave during propofol anaesthesia correlates with behavioural measures of the regaining of consciousness.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anesthesia / methods*
Animals
Evoked Potentials, Auditory / drug effects*
Evoked Potentials, Auditory / physiology
Female
Male
Propofol / pharmacology
Rats
Rats, Wistar
Reflex / drug effects*
Reflex / physiology

Substances

Propofol