Abstract
The hypothesis has been proposed that the GD3 ganglioside-like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis. Our study showed that patients with GBS or MFS who had previously suffered diarrhea had anti-GD3 antibodies less often than those who had not had diarrhea. Sera from patients who showed GBS or MFS with the serologic evidence of prior C. jejuni infection had anti-GD3 antibodies less frequently than sera from those without evidence of infection. Statistical analysis showed that anti-GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other antiganglioside antibodies, such as anti-GM1 antibodies. These results could not support the above hypothesis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Antibodies, Bacterial / blood*
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Campylobacter Infections / complications
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Campylobacter Infections / immunology*
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Campylobacter Infections / microbiology
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Campylobacter jejuni / immunology*
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Campylobacter jejuni / isolation & purification
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Case-Control Studies
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Diarrhea / etiology
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Diarrhea / immunology
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Epitopes
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Female
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Gangliosides / immunology*
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Gastroenteritis / complications
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Gastroenteritis / immunology*
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Gastroenteritis / microbiology
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Guillain-Barre Syndrome / etiology
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Guillain-Barre Syndrome / immunology*
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Guillain-Barre Syndrome / microbiology
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Humans
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Immunoglobulin G
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Lipopolysaccharides / immunology*
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Male
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Miller Fisher Syndrome / immunology
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Miller Fisher Syndrome / microbiology
Substances
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Antibodies, Bacterial
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Epitopes
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Gangliosides
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Immunoglobulin G
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Lipopolysaccharides
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ganglioside, GD3