Primary biliary cirrhosis associated with idiopathic retroperitoneal fibrosis

S Shikuwa-; K Omagari; Y Mizuta; K Murase; M Osabe; M Yoshimura; M Ohfukuji; Y Takehara; H Isomoto; M Ito; I Shimokawa; S Kohno

doi:10.1007/s005350070067

Primary biliary cirrhosis associated with idiopathic retroperitoneal fibrosis

J Gastroenterol. 2000;35(8):646-8. doi: 10.1007/s005350070067.

Authors

S Shikuwa-¹, K Omagari, Y Mizuta, K Murase, M Osabe, M Yoshimura, M Ohfukuji, Y Takehara, H Isomoto, M Ito, I Shimokawa, S Kohno

Affiliation

¹ Department of Internal Medicine, Nagasaki Chuo National Hospital, Omura, Japan.

PMID: 10955606
DOI: 10.1007/s005350070067

Abstract

Idiopathic retroperitoneal fibrosis (IRF) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report a 79-year-old man with the coexistence of both conditions. The patient had antibodies to both centromere and mitochondria, as indicated by indirect immunofluorescence. Diagnoses of IRF and PBC were confirmed histologically. Although the association between IRF and PBC is obscure, IRF may be involved in many autoimmune diseases associated with PBC.

Publication types

Case Reports

MeSH terms

Aged
Antibodies, Antineutrophil Cytoplasmic
Antibodies, Antinuclear / blood
Autoantibodies / blood
Centromere / immunology
Fluorescent Antibody Technique, Indirect
Humans
Liver Cirrhosis, Biliary / complications*
Liver Cirrhosis, Biliary / diagnosis
Liver Cirrhosis, Biliary / immunology
Liver Cirrhosis, Biliary / pathology
Magnetic Resonance Imaging
Male
Mitochondria / immunology
Retroperitoneal Fibrosis / complications*
Retroperitoneal Fibrosis / diagnosis
Retroperitoneal Fibrosis / immunology
Retroperitoneal Fibrosis / pathology

Substances

Antibodies, Antineutrophil Cytoplasmic
Antibodies, Antinuclear
Autoantibodies