3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity

J Med Chem. 2000 Jul 27;43(15):2779-82. doi: 10.1021/jm990945v.
No abstract available

MeSH terms

  • Animals
  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Brain / cytology
  • Brain / drug effects
  • Brain / metabolism
  • Drug Evaluation, Preclinical
  • Free Radical Scavengers / chemical synthesis*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • In Vitro Techniques
  • Iodoacetates
  • Lipid Peroxidation / drug effects*
  • Neuroprotective Agents / chemical synthesis*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology
  • Oxidative Stress / drug effects*
  • Pyridones / chemical synthesis*
  • Pyridones / chemistry
  • Pyridones / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Iodoacetates
  • Neuroprotective Agents
  • Pyridones
  • CEB 1370