Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate-induced neuronal death in cultured cerebellar granule cells

Phytother Res. 2000 Sep;14(6):466-8. doi: 10.1002/1099-1573(200009)14:6<466::aid-ptr614>3.0.co;2-z.

Abstract

We studied the protective effect of a water extract from the bark of Cinnamomum cassia Blume on glutamate-induced neuronal death by MTT assay and its action on (45)Ca(2+) influx using cultured rat cerebellar granule cells. In a dose-dependent manner, this extract (10(-5)-10(-4) g/mL) significantly protected against glutamate-induced cell death and also inhibited glutamate-induced (45)Ca(2+) influx. These results suggest that the bark of Cinnamomum cassia has a protective effect on glutamate-induced neuronal death through the inhibition of Ca(2+) influx.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cells, Cultured
  • Cerebellum / drug effects*
  • Cerebellum / pathology
  • Cinnamomum zeylanicum*
  • Glutamic Acid
  • Medicine, Kampo
  • Neurons / drug effects
  • Neurons / pathology
  • Neuroprotective Agents / pharmacology*
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Stems
  • Rats
  • Rats, Wistar

Substances

  • Neuroprotective Agents
  • Plant Extracts
  • Glutamic Acid