The use of glycoprotein IIb/IIIa inhibitors in patients with coronary artery disease

Am J Med. 2000 Aug 15;109(3):224-37. doi: 10.1016/s0002-9343(00)00474-5.

Abstract

Platelet membrane glycoprotein IIb/IIIa inhibitors, a new class of potent antiplatelet agents, have been used in the treatment of acute coronary syndromes as well as in the prevention of complications after percutaneous coronary interventions. Approximately 50,000 patients with coronary artery disease have been enrolled in randomized studies of glycoprotein IIb/IIIa inhibitors. The purpose of this article is to review the pharmacology of glycoprotein IIb/IIIa inhibitors, the results of the clinical trials using these agents, and their current use in percutaneous coronary interventions and the treatment of acute coronary syndromes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abciximab
  • Acetates / therapeutic use
  • Acute Disease
  • Administration, Oral
  • Alanine / therapeutic use
  • Angioplasty, Balloon, Coronary / methods
  • Antibodies, Monoclonal / therapeutic use
  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use*
  • Benzamidines / therapeutic use
  • Coronary Disease / drug therapy*
  • Coronary Disease / therapy
  • Eptifibatide
  • Hemorrhage / chemically induced
  • Humans
  • Immunoglobulin Fab Fragments / therapeutic use
  • Myocardial Infarction / drug therapy
  • Oximes / therapeutic use
  • Peptides / therapeutic use
  • Piperidines / therapeutic use
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Pyrrolidines / therapeutic use
  • Randomized Controlled Trials as Topic
  • Stents
  • Syndrome
  • Thrombocytopenia / chemically induced
  • Thrombolytic Therapy
  • Tirofiban
  • Tyrosine / analogs & derivatives*
  • Tyrosine / therapeutic use

Substances

  • Acetates
  • Antibodies, Monoclonal
  • Anticoagulants
  • Benzamidines
  • Immunoglobulin Fab Fragments
  • Oximes
  • Peptides
  • Piperidines
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Pyrrolidines
  • Tyrosine
  • lamifiban
  • orbofiban
  • Tirofiban
  • Eptifibatide
  • Alanine
  • xemilofiban
  • Abciximab
  • sibrafiban