Age-dependent effects of a chronic ultramild stress procedure on open-field behaviour in B6D2F1 female mice

Physiol Behav. 2000 Jul;70(1-2):7-13. doi: 10.1016/s0031-9384(00)00216-x.

Abstract

Few studies have been devoted to the interaction between age and stress. However, in view of the age-related changes in various components of the stress responses, the effects of stress may not be constant with age. In this study, we used a dimensional approach to compare open-field behaviour of B6D2F1 female mice, aged 5-6, 11-12, 17-18 and 23-24 months, exposed to a chronic ultramild stress (CUMS) procedure, solely based on nonnociceptive socioenvironmental stressors. Three behavioural dimensions emerged from the principal-component analysis; these were labelled as motor reactivity, exploratory activity, and emotional reactivity. Despite a major effect of age on the three dimensions, we could not conclude that CUMS had any influence as a function the age of the subjects. At all ages, CUMS increased motor activity and had no clear-cut effect on emotional reactivity and exploratory activity. The results are discussed in terms of the influence of the nature of the stressors on behavioural responses to novelty.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / psychology*
  • Analysis of Variance
  • Animals
  • Behavior, Animal / physiology*
  • Chronic Disease
  • Corticosterone / blood
  • Defecation
  • Emotions / physiology
  • Environment
  • Female
  • Grooming / physiology
  • Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Inbred Strains
  • Motor Activity / physiology
  • Social Environment
  • Stress, Psychological / psychology*

Substances

  • Corticosterone