Abstract
We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin side-chain analogues without compromising in vitro antifungal activity.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Fungi / drug effects
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Fungi / growth & development
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Microbial Sensitivity Tests
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology*
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Pseudomonas / chemistry
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Peptides, Cyclic
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pseudomycin A