Abstract
A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Fungi / drug effects
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Fungi / growth & development
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology*
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Pseudomonas / chemistry
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Peptides, Cyclic
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pseudomycin A