Identification of a new HLA-B*78 allele in a Hispanic family

Tissue Antigens. 2000 Aug;56(2):184-7. doi: 10.1034/j.1399-0039.2000.560215.x.

Abstract

A new B*78 variant, B*7804, was detected in three members of a Hispanic family. The novel B*78 sequence differs from B*78021 by two substitutions: T at nucleotide 527 (all other B*78s have A) and T at nucleotide 583 (all other B*78s have a C). Both nucleotide substitutions encode amino acid changes at codons 152 and 171, respectively.

MeSH terms

  • Alleles*
  • Exons
  • Family Health
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Hispanic or Latino / genetics*
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Single Nucleotide / immunology
  • Sequence Homology, Nucleic Acid

Substances

  • HLA-B Antigens

Associated data

  • GENBANK/AJ012471
  • GENBANK/AJ132713
  • GENBANK/AJ132714