Abstract
Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibody Formation*
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Autoantibodies / biosynthesis
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B-Cell Activating Factor
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology*
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Cell Differentiation
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Cell Movement
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DNA-Binding Proteins / physiology
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Humans
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Immune Tolerance
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Immunity, Innate
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Immunity, Mucosal
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Lymphocyte Activation*
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Lymphoid Tissue / cytology
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Lymphoid Tissue / immunology
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Membrane Proteins*
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Models, Immunological
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Signal Transduction
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T-Lymphocytes / immunology*
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Tumor Necrosis Factor-alpha / physiology
Substances
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Autoantibodies
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B-Cell Activating Factor
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DNA-Binding Proteins
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Membrane Proteins
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PD1 protein, pig
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TNFSF13B protein, human
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Tumor Necrosis Factor-alpha