Multiple endocrine neoplasia in a dog

J Comp Pathol. 2000 Aug-Oct;123(2-3):210-7. doi: 10.1053/jcpa.2000.0407.

Abstract

Multiple endocrine neoplasms, including an insulinoma, bilateral adrenocortical adenocarcinomas and an aortic paraganglioma, were diagnosed after euthanasia in a 12-year-old spayed female dog of mixed breed with a history of progressive anorexia, vomiting, diarrhoea, weight loss, polyuria and polydipsia, regenerative anaemia and hypoglycaemia. The clinical, gross pathological, microscopical, immunohistochemical and ultrastructural findings were consistent with the human syndrome of multiple endocrine neoplasia.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / metabolism
  • Adrenal Gland Neoplasms / pathology*
  • Adrenal Gland Neoplasms / ultrastructure
  • Animals
  • Chromogranin A
  • Chromogranins / analysis
  • Dogs
  • Fatal Outcome
  • Female
  • Immunohistochemistry
  • Insulin / analysis
  • Microscopy, Electron
  • Multiple Endocrine Neoplasia / metabolism
  • Multiple Endocrine Neoplasia / pathology*
  • Multiple Endocrine Neoplasia / ultrastructure
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / ultrastructure
  • Paraganglioma / metabolism
  • Paraganglioma / pathology*
  • Paraganglioma / ultrastructure
  • Phosphopyruvate Hydratase / analysis
  • S100 Proteins / analysis
  • Somatostatin / analysis
  • Synaptophysin / analysis

Substances

  • Chromogranin A
  • Chromogranins
  • Insulin
  • S100 Proteins
  • Synaptophysin
  • Somatostatin
  • Phosphopyruvate Hydratase