Abstract
Tamoxifen exhibits favorable effects on the lipid and lipoprotein profile since it decreases the total and LDL cholesterol levels as well as the Lp(a) levels. Additionally, a small increase in serum triglycerides is commonly found after tamoxifen administration. However, severe hypertriglyceridemia which can sometimes be associated with life-threatening complications is occasionally noticed. Herein, we describe a patient who developed tamoxifen-induced severe hypertriglyceridemia and pancreatitis. An analysis of the underlying pathogenetic mechanisms as well as a review of the relevant literature is also provided.
MeSH terms
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Antineoplastic Agents, Hormonal / adverse effects*
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Antineoplastic Agents, Hormonal / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Breast Neoplasms / drug therapy*
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Cisplatin / administration & dosage
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Female
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Fluorouracil / administration & dosage
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Humans
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Hypertriglyceridemia / chemically induced*
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Methotrexate / administration & dosage
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Middle Aged
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Pancreatitis / chemically induced*
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Tamoxifen / adverse effects*
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Tamoxifen / therapeutic use
Substances
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Antineoplastic Agents, Hormonal
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Tamoxifen
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Cisplatin
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Fluorouracil
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Methotrexate