Two-step immunoablative treatment with autologous peripheral blood CD34(+) cell transplantation in an 8-year-old boy with autoimmune haemolytic anaemia

Br J Haematol. 2000 Sep;110(4):900-2. doi: 10.1046/j.1365-2141.2000.02281.x.

Abstract

Life-threatening haemolysis in children with autoimmune haemolytic anaemia (AIHA) occurs rarely. Many cases of severe autoimmune disease are currently treated with immunosuppressive high-dose chemotherapy and autograft. We report here a case of a child with severe AIHA who did not respond to conventional treatments, but was cured with an autologous peripheral blood CD34(+) cell transplantation. After d 16 post autograft, no further red cell transfusions were required. At 20 months post autograft, haematological complete remission persists.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic, Autoimmune / therapy*
  • Antigens, CD34*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carmustine / therapeutic use
  • Child
  • Cyclophosphamide / therapeutic use
  • Cytarabine / therapeutic use
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Melphalan / therapeutic use
  • Methylprednisolone / therapeutic use
  • Plasmapheresis
  • Podophyllotoxin / therapeutic use
  • Prednisolone / therapeutic use
  • Splenectomy
  • Stem Cells / immunology*
  • Transplantation, Autologous
  • Treatment Outcome

Substances

  • Antigens, CD34
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents
  • Cytarabine
  • Cyclophosphamide
  • Prednisolone
  • Podophyllotoxin
  • Melphalan
  • Carmustine
  • Methylprednisolone

Supplementary concepts

  • BEAM protocol