Abstract
Studies in various animal species have recently shown that (99m)Tc-BIG has practical and dosimetric benefits for renal imaging that could probably make it a good alternative to (99m)Tc-2, 3-dimercaptosuccinic acid ((99m)Tc-DMSA). In this study, using the baboon experimental model, the biodistribution of (99m)Tc-BIG and (99m)Tc-DMSA are compared. It is demonstrated that early good contrast imaging and more favourable dosimetry is possible with (99m)Tc-BIG compared to (99m)Tc-DMSA, confirming the quoted previous findings with small animals. Time-activity curves for kidneys and other organs support these findings, and MIRDOSE software provided the dosimetry.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biguanides / pharmacokinetics*
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Drug Evaluation, Preclinical
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Heart / diagnostic imaging
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Kidney / diagnostic imaging*
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Kidney / metabolism
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Liver / diagnostic imaging
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Liver / metabolism
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Lung / diagnostic imaging
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Lung / metabolism
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Male
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Metabolic Clearance Rate
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Models, Biological
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Myocardium / metabolism
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Papio
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Radionuclide Imaging
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Radiopharmaceuticals / pharmacokinetics*
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Radiotherapy Planning, Computer-Assisted
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Spleen / diagnostic imaging
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Spleen / metabolism
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Technetium Tc 99m Dimercaptosuccinic Acid / pharmacokinetics*
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Tissue Distribution
Substances
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Biguanides
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Radiopharmaceuticals
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technetium Tc 99m biguanide
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Technetium Tc 99m Dimercaptosuccinic Acid