Investigation of the lipophilic extract of the sponge Strepsichordaia aliena revealed six new 20,24-bishomoscalarane sesterterpenes, honu'enone (1), phyllofolactones H-K (3-6), and phyllofenone C (7). Structure elucidation of these compounds was secured by spectroscopic methods, 1D and 2D NMR, and accurate mass measurements.