Abstract
Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity.
MeSH terms
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Animals
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Benzylidene Compounds / chemical synthesis*
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Benzylidene Compounds / chemistry
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Benzylidene Compounds / pharmacology*
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Cell Line
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Dose-Response Relationship, Drug
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Drug Design
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Drug Evaluation, Preclinical
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology*
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Insulin / metabolism*
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Insulin Secretion
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Mice
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Molecular Structure
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Structure-Activity Relationship
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Succinates / chemical synthesis*
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Succinates / chemistry
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Triglycerides / metabolism
Substances
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Benzylidene Compounds
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Hypoglycemic Agents
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Insulin
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Succinates
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Triglycerides