Abstract
Five new derivatives of hypocrellin B were obtained from the reactions of hypocrellin B with ammonia and ethanolamine. Their photophysical and photochemical properties were investigated. The phototoxicity of one compound on AH cells irradiated with red light (lambda = 600-700 nm) was also studied. Their significantly enhanced red absorptivities at wavelengths longer than 600 nm and singlet oxygen-generating function qualify them as promising photodynamic therapy agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ammonia / chemistry
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Animals
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Cell Survival / drug effects
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Ethanolamine / chemistry
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Liver Neoplasms, Experimental
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Molecular Structure
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Oxygen
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Perylene / analogs & derivatives*
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Perylene / chemistry
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Perylene / toxicity
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Photochemistry
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / toxicity
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Quinones / chemical synthesis*
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Quinones / chemistry*
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Quinones / toxicity
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Singlet Oxygen
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Photosensitizing Agents
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Quinones
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Singlet Oxygen
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Ethanolamine
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Perylene
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Ammonia
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Oxygen
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hypocrellin B