Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient

Bone Marrow Transplant. 2000 Nov;26(9):1021-4. doi: 10.1038/sj.bmt.1702593.

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is a complication of allogeneic bone marrow transplantation (BMT). Rare cases of PTLD after autologous BMT have been reported only in adults. This case report is the first to describe PTLD in a pediatric patient after autologous peripheral stem cell transplantation (PSCT). This 2-year-old male with stage IV neuroblastoma underwent autologous PSCT. The post-PSCT course was complicated by fever with hematochezia and a lung mass. On day 94 post PSCT, colonoscopy revealed an ulcer due to a PTLD, monomorphic type, B cell phenotype, associated with Epstein-Barr virus. Fine needle aspiration identified the lung mass as neuroblastoma. PTLD can occur in pediatric autologous PSCT recipients, and may occur more frequently in autologous grafts manipulated by T cell depletion or CD34+ cell selection.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Gland Neoplasms / drug therapy
  • Adrenal Gland Neoplasms / surgery
  • Adrenal Gland Neoplasms / therapy*
  • Adrenalectomy
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child, Preschool
  • Cisplatin / administration & dosage
  • Colonic Diseases / etiology
  • Colonic Diseases / virology
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cytomegalovirus Infections / etiology
  • Doxorubicin / administration & dosage
  • Duodenal Ulcer / etiology
  • Duodenal Ulcer / virology
  • Epstein-Barr Virus Infections / complications
  • Etoposide / administration & dosage
  • Gastrointestinal Hemorrhage / etiology
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects*
  • Lung Neoplasms / secondary
  • Lymphatic Metastasis
  • Lymphoma, Large B-Cell, Diffuse / etiology*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Male
  • Neuroblastoma / drug therapy
  • Neuroblastoma / secondary
  • Neuroblastoma / surgery
  • Neuroblastoma / therapy*
  • Orbital Neoplasms / secondary
  • Prion Diseases
  • Transplantation Conditioning / adverse effects*
  • Transplantation, Autologous
  • Ulcer / etiology
  • Ulcer / virology
  • Vincristine / administration & dosage

Substances

  • Immunosuppressive Agents
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin