The study was carried out of 9742 blood cultures obtained in 1993-1998 from patients of selected departments of the University Hospital. The received samples were assessed from the standpoint of the participation of fungi strains of clinical importance as aetiological factors in systemic infections and the resistance status of a selected group of pathogens. Microbiological blood studies were conducted in the system of continuous monitoring of the obtained cultures by means of the automatic ATB system using a commercially available ID 32C set. ATB Fungus tests were used for drug resistance assessment. In all, 95 strains of yeasts (5.1%) were obtained in cultures, and an increasing variety of these pathogenic species was noted in sepsis. A systematic reduction was noted in the proportion of C. albicans and a steep rise of C. parapsilosis were observed among the aetiological factors of generalized nosocomial fungal infections. A tendency was noted for a continuous rise in the frequency of invasive candidemias with a most significant rise in their proportion in patients in general surgery and haematology departments. Among the fungi isolated from septic complications the proportion of strains resistant to antifungal drugs has been rising.